Human Biology

Researchers at the Francis Crick Institute have pieced together genetic and molecular changes that lead to a rare progressive neurodegenerative condition called ataxia with oculomotor apraxia 2.

Researchers at the Francis Crick Institute have developed a new mass spectrometric acquisition technology, Scanning SWATH, that measures the human proteome substantially faster and at a lower cost than its predecessors. The scientists hope this technology will lead to more effective drug screening and biomarker discovery.

Where do we come from? It’s a fundamental question in our understanding of what it means to be human. Yet, there are many gaps in our history, including the location of where modern humans - Homo sapiens - originated thousands and thousands of years ago.

A team in South Africa has sequenced and analysed six whole human genomes, the first time this process has been carried out in South Africa.

Pioneering scientists at the Francis Crick Institute, Great Ormond Street Hospital (GOSH) and UCL Great Ormond Street Institute of Child Health (ICH) have grown human intestinal grafts using stem cells from patient tissue that could one day lead to personalised transplants for children with intestinal failure, according to a study published in Nature Medicine.

Researchers at the Francis Crick Institute have found two genes that regulate the differentiation of stem cells in the small intestine, offering valuable insight into how the body develops and maintains a healthy gut.

The US National Academy of Sciences (NAS) has elected John Diffley, Associate Research Director at the Francis Crick Institute, as a member in recognition of his distinguished and continuing achievements in cancer research.

Cristina Dias is a clinical geneticist and clinician scientist in Francois Guillemot’s group at the Crick, studying the molecular mechanisms of a group of neurodevelopment disorders. John Roberts is a parent of a child who is part of a clinical study led by Cristina at Great Ormond Street Hospital.